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# Biginelli Reaction

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 Sub Topics The Biginelli reaction involves an one-pot reaction between aldehyde and urea or thiourea in the presence of an acidic catalyst to afford 3,4-dihydropyrimidin-one. This reaction is also referred to as the Biginelli condensation and Biginelli dihydropyrimidine synthesis. It belongs to a class of transformations called multi-component reactions. Biginelli reaction is an excellent promoter for the one pot synthesis of dihydroppyrimidinones via the Biginelli reaction, which involves the condensation of an aldehyde, a $\beta$-keto esterand urea. The traditional Biginelli reaction commonly proceeds under strongly acidic conditions and this protocol often suffers from low yields particularly in case of substituted aromatic or aliphatic aldehydes.