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# Baeyer Villiger Oxidation

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 Sub Topics The Bayer-Villiger oxidation is a useful method for conversion of aldehydes and ketones to esters by the insertion of an oxygen atom from a peroxycarboxylic acid (RCO3H). For example, treating acetophenone with a peroxycarboxylic acid converts it to the ester phenyl acetate.

## Mechanism

The Baeyer-Villiger oxidation is also widely used for synthesizing lactones from cyclic ketones. A common reagent used to carry out the Baeyer-Villiger oxidation is m-chloroperoxybenzoic acid. Certain other peroxycarboxylic acids can be used as well and we will discuss shortly a "green" variation of the Baeyer-Villiger oxidation by a peroxycarboxylic acid.

The following is a mechanism proposed for Baeyer-Villiger oxidation by a peroxycarboxylic acid.

## Baeyer-Villiger Monooxygenase

Asymmetric oxidations play an important role in organic synthesis. Many valuable highly efficient chemocatalytic methods have been developed. Besides chemocatalysts, enzymes turned out to present useful catalysts. Notably a broad range of different types of oxidation reactions can be catalyzed by bio catalysts.

To start with the oxidation of a carbon atom, one can convert a ketone moiety into an ester in an asymmetric fashion by means of a so called Baeyer-Villiger monooxygenase.

## Examples

Baeyer-Villiger oxidation of a Mannich base having an appropriate substituent for selective migration on to the oxo carbonyl group opens a valuable possibility for the synthesis of $\beta$-amino esters and acids. Examples are the synthesis of epi-cytoxazone and the $\alpha$-hydroxy-$\beta$-amino acid derivatives from ketones respectively.